Actively Recruiting Studies

This page lists ongoing clinical research studies at The Royal that are currently seeking volunteer participants and/or healthy control volunteers. 

We invite you to browse through the list below to search for studies that may interest you. 

Note: Participation in mental health research is always voluntary and we encourage you to discuss the clinical study with your physician before getting involved.

*All clinical studies have been approved by The Royal’s Research Ethics Board

Want to participate in research, but aren’t eligible for any of our current studies? Sign up for The Royal’s voluntary Permission to Contact for Research registry, so that we can get in touch with you about upcoming research opportunities that you may be eligible for.

For more information about clinical research at The Royal, contact tammy.beaudoin@theroyal.ca.

MOOD DISORDERS RESEARCH

POPULATION AGE & GENDER STUDY NAME STUDY DESCRIPTION
Are currently experiencing depression,
free of pharmacotherapy, and are not currently engaging in regular moderate or vigorous intensity exercise
  • 16-24 years
  • Male and Female
Assessing the clinical & neural outcomes in depressed youth randomized to one of two Intensities of aerobic exercise

This study will assess the effects of moderate versus high intensity aerobic exercise on symptoms of depression, cognitive functioning and brain function.

 

Click here to learn more about this study.

Are referred to the ECT service at The Royal Ottawa Mental Health Centre and have a current diagnosis of a mood disorder
  • 60 years and over
  • Male and Female 
Effects of electroconvulsive therapy on brain activity during sleep in late-life depression

Study evaluates the effects of ECT on brain activity during sleep in elderly persons with depression.

 

Click here to learn more about this study

Have a current diagnosis of depression or bipolar disorder or have no history of a mental or sleep disorder
  • 13-35 years
  • Male and Female 
Effects of mood disorders on electrophysiological measures of central executive and emotional processing in adolescents: an ERP study

Study aims to find out the brain’s involvement in attention, higher thinking skills, and emotional processing in children, adolescents and young adults with and without depression.

 

Click here to learn more about this study. 

A current diagnosis of a mood disorder (depression, bipolar disorder, dysthymia)
  • 13-35 years
  • Male and Female
Phototherapy for early-onset depression: Associations between sleep and mood changes

Study tests whether the sleep and “body clock” profile of young people with depression influences their response to light therapy.

 

Click here to learn more about this study

Have a primary diagnosis of a depressive disorder. Patients may have comorbidity of any non-psychotic disorder, as well as PTSD and/or mTBI
  • 18-65 years
  • Male and Female
A prospective, blinded, randomized, multicenter study to evaluate the utility, safety, and efficacy of using PEER Interactive to inform the prescription of medications to patients with a primary diagnosis of a depressive disorder and comorbidity of non-psychotic behavioural disorders versus treatment as usual
 

Study is to improve the prescription accuracy of psychotropic medications for military personnel diagnosed with neuropsychiatric disorders and related conditions.

 

Click here to learn more about this study

Major Depressive Disorder or Healthy Volunteer
  • 18-65 years
  • Male and Female
Impacts of early-life adversity on microbiota and immune alterations in individuals with Major Depressive Disorder

Study objective is to determine if perturbations within the immune system and the gut microbiome are more pronounced in individuals with a history of childhood adversity and are aligned with the presence and severity of depressive symptoms.

 

Click here to learn more about this study

Have a primary Diagnosis of Major Depressive Disorder
  • 18-65 years
  • Male and Female
Charactering suicidal ideation in treatment-resistant depression using neuroimaging

This study is using brain imaging to understand brain changes associated with depression in people with and without suicidal thoughts. Researching potential risk factors will help us establish more accurate and detailed risk profiles.

 

Click here to learn more about this study

Have a current diagnosis of mood disorder, post-traumatic stress disorder, or psychotic disorders

 

OR

 

Have been referred to the Sleep Disorders Clinic of the Royal Ottawa Mental Health Centre

 

OR

 

Have no previous history of a mental or sleep disorder

  • Any age
  • Any gender
Sleeping and health improvements: following longitudinal trajectories (SHIFT)

This study aims to evaluate the link between sleep and the heart, brain and mind.

 

Click here to learn more about this study

Major Depressive Disorder or Episode

18 years of age and older

Any gender

A naturalistic study comparing the efficacy of uni- and bi-lateral theta burst stimulation in treating major depression

Clinical trial investigating uni- and bi-lateral theta burst stimulation with participants who have major depressive disorder or episode and are treatment-resistant. 

 

Click here to learn more about this study. 

SCHIZOPHRENIA RESEARCH

POPULATION AGE & GENDER STUDY NAME STUDY DESCRIPTION
Currently have a diagnosis related to psychosis (e.g., schizophrenia, schizoaffective, schizophreniform, delusional, BP with psychotic features, etc.)
  • 18-65 years
  • Male and Female 
A longtitudinal naturalistic exploration of outcome and recovery in schizophrenia and related psychoses using a clinically based research evaluation (CBRE)

The purpose of this study is to identify factors related
to outcomes and recovery in schizophrenia and other
diagnoses related to psychosis.

 

Click here to learn more about this study

Are a current inpatient, outpatient or day program patient of the Schizophrenia or Recovery Program
  • 16-65 years
  • Male and Female
Is there a difference in uptake of Paliperidone Palmitate between the deltoid and ventrogluteal injection sites?

Study examines if there is a difference in uptake of Paliperidone Palmitate (Sustenna) between the deltoid (arm) and ventrogluteal (hip) injection sites.

 

Click here to learn more about this study.

Are a current inpatient or outpatient of the Schizophrenia Recovery Program
  • 18-65 years
  • Male and Female
Electroconvulsive therapy in treatment-resistant schizophrenia: comparison of the use of ketamine vs. other anesthetics during ECT

This study aims to compare the efficacy of adjunct ECT in patients with treatment resistant schizophrenia considering the use of ketamine versus other anesthetics.

 

Click here to learn more about this study.

FORENSIC RESEARCH

POPULATION AGE & GENDER STUDY NAME STUDY DESCRIPTION
All patients receiving treatment within the forensic program at the Brockville Mental Health Centre and The Royal Champlain site
  • 18 and over
  • Male and Female
Anger and psychopathology in a forensic patient population: a look at psychiatric diagnosis in family members

The purpose of the present study is to investigate the nature of the association between dysfunctional anger, personal and familial psychopathology, and aggression within a sample of Forensic patients.

 

Click here to learn more about this study. 

Men who have had adverse childhood experiences
  • 18 to 60 years
  • Male
A qualitative investigation of the relationship between adverse childhood experiences and hands-on versus hands-off sexual offences against children

The goal of this study is to gain a better understanding of the relationship between adverse childhood experiences (ACEs) and sexual offending against children.

 

Click here to learn more about this study

Men with a sexual interest in children and men with no sexual interest in children
  • 18-65 years
  • Male
Real people vs. not real people: comparing the accuracy of two stimuli sets in determining sexual preference in men with sexual interest in children

The purpose of this study is to undergo new testing material in the forensic lab.

 

Click here to learn more about this study

Men who have no strong unusual erotic interests OR men who have strong interests in women’ feet
  • 18 and over
  • Male
Are connectivity differences unique to pedophilia?

This brain imaging study on erotic responses involves answering questions in an interview, completing questionnaires, and participating in a brain scanning session. 

 

Click here to learn more about this study

Men with a sexual interest in children
  • 18-65 years
  • Male
Phallometric verification of change in men’s sexual interest in children

Study includes two phallometric sessions in order to compare responses across both time periods.

 

Click here to learn more about this study

Men who admit to having a sexual interest in children but never received treatment for this interest
  • 18 and over
  • Male
Moving toward prevention: encouraging men with a sexual interest in children to seek treatment before offending

Study to help men with a sexual interest in children get treatment before acting on this interest. Participation involves completing a package of questionnaires at two times points (first appointment and six months later).

 

Click here to learn more about this study

RESEARCH WITH HEALTHY PARTICIPANTS

POPULATION AGE & GENDER STUDY NAME STUDY DESCRIPTION
Healthy Participants
  • 18-40 years
  • Male
Effectiveness of the norepinephrine and serotonin reuptake inhibitor Levomilnacipran in healthy males

The study involves taking antidepressants (already on the Canadian market, not experimental) in order to test levels of neurotransmitters.

 

Click here to learn more about this study

Right-Handed Healthy Participants
  • 25-35 years
  • Male and Female
Neural correlates of cognitive procedural memory consolidation during sleep

This study will look at brain activity related to learning a new task. Brain activity will be recorded using functional Magnetic Resonance Imaging (fMRI) and Electroencephalography (EEG), two non-invasive techniques.

 

Click here to learn more about this study