Characterizing suicidal ideation in treatment-resistant depression using neuroimaging

We are using imaging to look for characteristics of brain structure and/or function in individuals with major depressive disorder (MDD) who have suicidal thoughts. We are seeking healthy individuals for comparison. Participants will undergo one magnetic resonance imaging (MRI) scan, and will be compensated $50 for their efforts.

Age range

18-65 years of age


Males and females

Individuals are eligible if they:

  • Are between 18 and 65 years of age, inclusive
  • Have the ability to understand and comply with the requirements of the study, as judged by the investigator(s)

Individuals are not eligible if they:

  • Have a diagnosis of any psychiatric disorder as confirmed by the Research Version of the Scheduled Clinical Interview for DSM-5 (SCID-5-RV; First et al., 2015)
  • Have a lifetime history of active suicidal ideation (Columbia Suicide Severity Rating Scale [C-SSRS; Posner et al., 2008] SI severity score > 1), or history of suicidal behaviours or attempts
  • Have a diagnosis of substance-related abuse in the past 6 months or a lifetime diagnosis of substance dependence according to DSM-5 criteria (excluding caffeine or nicotine)
  • Have a positive urine toxicology screen for drug use
  • Positive pregnancy test at screening
  • Have a presence or history of significant head trauma, traumatic brain injury, stroke, seizures, or previous brain surgery
  • Have any contraindications to MRI scanning

Location of study 

The Royal’s Institute of Mental Health Research, affiliated with the University of Ottawa
1145 Carling Ave, Ottawa, ON 

Recruitment via

Self-Referral (by participant) 
Internal Referral (by ROMHC staff) 
External Referral (by doctors or other mental health specialist outside of ROMHC) 

Principal Investigator

Dr. Jennifer Phillips, PhD


Kimia Owsia

*This study is currently recruiting participants